Compound in Chili pepper May Halt Lung Cancer

Compound in chili pepper may halt spread of lung cancer

Compound in chili pepper may halt spread of lung cancer, according to study. Capsaicin, the spicy compound in chili peppers may successfully stop the spread of lung cancer, according to a new study.
Most cancer-related deaths is as a result of the cancer spreading, to distant parts of the body. New research suggests that there may be a nutritional compound in chili pepper that can stop the spread of lung cancer. A chemical compound in chili peppers called capsaicin, which is responsible for the strong flavor of the compound, was able to stop the metastasis of lung cancer in rodents and cultured human cell lines.
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Senior researcher of the new study, Piyali Dasgupta, Ph.D., from the Marshall University Joan C. Edwards School of Medicine in Huntington, WV. Also the first author of the study is Jamie Friedman, a doctoral researcher in Dasgupta’s lab.

How Compound in Chili pepper May Halt Lung Cancer

For the study, the team of researchers tested capsaicin in three cultured lines of human non-small cell lung cancer cells. They discovered that capsaicin stopped the first stage of spread called “invasion.”
Also, the team fed mice with lung cancer a diet enhanced with capsaicin. They found that these rodents had a much smaller number of metastatic cancer cells in their lungs compared with mice that did not receive the treatments.
Additional experiments found that capsaicin stopped metastasis in lung cancer by obstructing the activation of the Src protein. This is a protein that is key in regulating the multiplying, survival, and motility of the cells.
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Based on the results, Friedman and colleagues came up with this conclusion:
“Capsaicin directly interacts with Src and inhibits Src activation to suppress the metastasis of lung cancer. The results of our studies may foster the development of novel anti-metastatic therapies for human lung cancer.”
The researchers noted that they need to develop capsaicin analogs that would dodge its side effects.
“We hope that one day capsaicin can be used in combination with other chemotherapeutics to treat a variety of lung cancers. However, using capsaicin clinically will require overcoming its hostile side effects,” says Friedman.
Some unpleasant side effects of using capsaicin include:
  • Stomach cramps
  • Gastrointestinal irritation
  • Burning sensation.
Lung cancer and other cancers commonly metastasize to secondary locations like the brain, liver, or bone, making them difficult to treat.
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According to Friedman, “Our study suggests that the natural compound capsaicin from chili peppers could represent a novel therapy to combat metastasis in lung cancer patients.”

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