The Nationwide Institute of Allergy and Infectious Ailments (NIAID), a part of the Nationwide Institutes of Well being, right now introduced the scientific investigators and establishments that may lead 4 NIH HIV scientific trials networks over the following seven years to conduct the progressive, environment friendly scientific analysis wanted to speed up progress towards the HIV pandemic. NIAID additionally awarded grants to 35 U.S. and worldwide establishments chosen as HIV scientific trials models (CTUs). NIAID and co-funding NIH Institutes intend to supply roughly $375.three million within the first yr to help the networks.
“Attaining a sturdy finish to the HIV pandemic would require continued improvement of recent HIV prevention and remedy methods, in addition to optimum implementation of present instruments,” stated NIAID Director Anthony S. Fauci, M.D. “The brand new community construction will improve the effectivity and effectiveness of NIH’s HIV scientific trial operations to expediently tackle the crucial analysis questions that may deliver us nearer to this purpose, whereas all the time making certain the protection of scientific trial contributors.”
The method of refining the NIH HIV scientific trials networks started in 2017 and concerned in depth consultations with researchers, clinicians, advocates, individuals with or susceptible to HIV, and different stakeholders. The brand new, streamlined community construction will cut back administrative and oversight prices, permitting extra funds to be allotted to scientific trials to advance 4 key areas of analysis emphasis: HIV prevention; HIV vaccines; HIV/AIDS grownup therapeutics; and HIV/AIDS maternal, adolescent and pediatric therapeutics. The networks even have the pliability to leverage their infrastructure to quickly reply to rising infectious ailments, equivalent to coronavirus illness 2019 (COVID-19).
The brand new construction consists of one community that may deal with improvement of a secure, efficient and sturdy preventive HIV vaccine, and one that may work to advance an array of non-vaccine HIV prevention merchandise and methods to fulfill the wants and preferences of numerous populations worldwide. Two therapeutics networks will develop and consider potential new remedies and treatment methods for HIV and HIV-related issues and co-infections. One among these networks will deal with adults, whereas the opposite will deal with infants, youngsters, adolescents, and pregnant and postpartum ladies. HIV prevention and vaccine analysis for the maternal, pediatric and adolescent populations can be led by the HIV prevention and vaccine networks, with help from the therapeutics community targeted on these populations.
The 4 networks will direct, coordinate and conduct NIH-funded scientific analysis worldwide in shut collaboration with each other, NIAID, different accomplice NIH Institutes and Facilities, trade and non-governmental analysis organizations. Every community is led by a management and operations middle (LOC) and features a laboratory middle (LC) and a statistical and knowledge administration middle (SDMC). The principal investigators, establishments and grant numbers for these awards are as follows:
HIV Vaccine Trials Community (HVTN)
- LOC: Lawrence Corey, Dan H. Barouch, Glenda E. Grey, Georgia D. Tomaras; Fred Hutchinson Most cancers Analysis Middle, Seattle; 2 UM1 AI068614-15
- LC: Margaret J. McElrath; Fred Hutchinson Most cancers Analysis Middle, Seattle; 2 UM1 AI068618-15
- SDMC: Peter B. Gilbert, Yunda Huang, Holly Janes; Fred Hutchinson Most cancers Analysis Middle, Seattle; 2 UM1 AI068635-15
HIV Prevention Trials Community (HPTN)
- LOC: Myron S. Cohen, Wafaa M. El-Sadr; Household Well being Worldwide, Durham, North Carolina; 2 UM1 AI068619-15
- LC: Susan H. Eshleman; Johns Hopkins College, Baltimore; 2 UM1 AI068613-15
- SDMC: Deborah J. Donnell; Fred Hutchinson Most cancers Analysis Middle, Seattle; 2 UM1 AI068617-15
AIDS Medical Trials Group (ACTG)
- LOC: Judith S. Currier, Joseph J. Eron; College of California Los Angeles; 2 UM1 AI068636-15
- LC: Grace M. Aldrovandi; College of California Los Angeles; 2 UM1 AI106701-08
- SDMC: Michael D. Hughes, Marlene Cooper; Harvard College of Public Well being, Boston; 2 UM1 AI068634-15
Worldwide Maternal Pediatric Adolescent AIDS Medical Trials Community (IMPAACT)
- LOC: Sharon A. Nachman; Johns Hopkins College, Baltimore; 2 UM1 AI068632-15
- LC: Grace M. Aldrovandi; College of California Los Angeles; 2 UM1 AI106716-09
- SDMC: David E. Shapiro, Marlene Cooper; Harvard College of Public Well being, Boston; 2 UM1 AI068616-15
The 35 CTUs will present scientific and administrative experience, in addition to the infrastructure to conduct scientific trials throughout the networks. A whole listing of CTUs, together with principal investigators and their affiliations, is out there on-line. Every CTU helps as much as eight scientific analysis websites. Collectively, the CTUs help 101 scientific analysis websites in 18 international locations throughout North America, South America, Africa and Asia. This consists of 45 websites in america. View a map exhibiting the scientific analysis website areas.
The opposite NIH Institutes that may collaborate with a number of of the HIV scientific trials networks embrace the Eunice Kennedy Shriver Nationwide Institute of Youngster Well being and Human Growth (NICHD); the Nationwide Institute of Dental and Craniofacial Analysis (NIDCR); the Nationwide Institute on Drug Abuse (NIDA); the Nationwide Institute of Psychological Well being (NIMH); and the Nationwide Institute of Neurological Issues and Stroke (NINDS).
To be taught extra about these new awards and the method to refine NIH’s HIV scientific trials networks, see NIAID’s Refining the HIV Medical Trials Enterprise web site.
NIAID conducts and helps research–at NIH, all through america, and worldwide–to research the causes of infectious and immune-mediated ailments, and to develop higher technique of stopping, diagnosing and treating these sicknesses. Information releases, truth sheets and different NIAID-related supplies can be found on the NIAID web site.
Concerning the Nationwide Institutes of Well being (NIH):
NIH, the nation’s medical analysis company, consists of 27 Institutes and Facilities and is a part of the U.S. Division of Well being and Human Providers. NIH is the first federal company conducting and supporting fundamental, scientific, and translational medical analysis, and is investigating the causes, remedies, and cures for each frequent and uncommon ailments. For extra details about NIH and its applications, go to http://www.
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